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  • Adaptation: Modification of an EBP change to improve the fit with the local setting.

  • Adoption: Active decision by an individual, organization, or community to change behaviors and use an EBP because of the benefit or relative advantage offered.

  • AGREE II (Appraisal of Guidelines for Research & Evaluation II): Established tool that provides a framework for assessing the quality and reporting of clinical practice guidelines (CPGs).

  • Anecdotal evidence: Informal reports supported by local experts, local data, theory, or scientific principles.

  • Balancing measures: Indicators that monitor for systemic effects, risks, and unintended consequences from the EBP change.

  • Body of evidence: Relevant research, synthesis reports, patient preferences, case reports, local data, and expert opinion that answers clinical questions and guides development of practice recommendations.

  • Bottom-up: Clinical problems and solutions driven by frontline clinicians and elevated to leaders.

  • Capacity: Ability or power to do or produce, as in building ability, skills, and resources to achieve more.

  • Case-control study: Retrospective design where subjects with a certain outcome or disease (cases) are grouped and then exposures (risks) are compared to matched controls.

  • Case report: Retrospective account of an individual or select individuals with unusual or pertinent diseases, interventions, or therapies.

  • Change agent: Influential person who, based on their role, expertise, or leadership style, can impact adoption of an EBP change.

  • Climate: How the work environment is experienced.

  • Clinical practice guidelines (CPGs): Document including recommendations for or against related assessments, procedures, tests, or interventions; based on a systematic review of evidence and analysis of benefits versus harms intending to change clinician practices and to optimize patient care.

  • Clinical practice recommendation: Statements informed by evidence that include authoritative suggestions intended to optimize patient care.

  • Clinical significance: Effect of the EBP change in a real-world setting showing a meaningful difference in outcomes.

  • Co-design: Method to engage patients as equal partners in planning the EBP change.

  • Cohort study: Design in which prospective subjects are grouped by exposure (cohort) and followed over time to determine outcomes.

  • Consensus statement: Report of a panel of experts based on their evaluation of the state of scientific knowledge available at the time, with a determination for practice.

  • Consistency of evidence: Degree to which studies report similar results or have similar implications for practice.

  • Context: Setting within which an EBP change is designed to be used; includes the social, regulatory, norms, and cultures of the setting.

  • Continuous data: Information that is measured and can take any value and can be divided in half (e.g., lab values, weight).

  • Core components: Key behaviors or active ingredients identified from the best evidence for use in the EBP change that are essential for achieving outcomes.

  • Cross-sectional study: Prospective observational design that examines health status, behavior, and other risk factors of a subpopulation measured at a given time.

  • Decision support: Filtered and timely information to reduce delays, increase accuracy, reduce risks, and standardize practices.

  • De-implementation: Stopping or removing practices that are not evidence-based, do not improve care, are ineffective, and may be harmful.

  • Diffusion: Passive spread of an ...

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