| Abciximab |
| Bolus dose | 0.25 mg/kg | In 250 mL | Bolus infused over 1-5 minutes |
| Infusion dose | 0.125 mcg/kg/min for 12 hours | | Maximum infusion rate = 10 mcg/min |
| Acetaminophen | 1 g q6h | | Maximum dose of 4 g in 24 hours |
| Acetazolamide | 5-10 mg/kg/24 h or 250 mg qd-qid | Undiluted | Infuse over 1-3 minutes with maximum infusion rate of 500 mg/min |
| Acyclovir | 5-15 mg/kg q8h | In 100 mL | Infuse over at least 60 minutes |
| Adenosine | 6 mg initially, then 12 mg × 2 doses PRN | Undiluted | Inject over 1-2 seconds |
| | | | Drug interactions: theophylline (1), persantine (2), caffeine, carbamazepine |
| Alteplase |
| Acute MI | 100 mg over 3 hours | 100 mg in 200 mL | In acute MI, infuse 10 mg over 2 minutes, then 50 mg over |
| PE | 100 mg over 2 hours | | 1 hour, and then 40 mg over 2 hours |
| Ischemic stroke | 0.9 mg/kg (not to exceed 90 mg) | | 10% of total dose as IV bolus over 1 minute, then remaining 90% as IV infusion over 60 minutes |
| Amikacin |
| Standard dose | 5-7.5 mg/kg q12h | In 50 mL | Infuse over 30 minutes |
| Single daily dose | 15-20 mg/kg q24h | In 50 mL | Drug interactions: neuromuscular blocking agents (3) |
| | | | Therapeutic levels: Peak: 20-40 mg/L; trough: < 8 mg/L Single daily dose: trough level at 24 hours = 0 mg/L; peak levels unnecessary |
| Amiodarone | 150-300 mg, which may be followed by 150 mg IV × 1 PRN | | Infuse continuously at 1 mg/min for 6 hours then reduce to 0.5 mg/min for 18 hours |
| Ammonium chloride | mEq Cl = Cl deficit (in mEq/L) × 0.2 × wt (kg) | 100 mEq in 500 mL | Maximum infusion rate is 5 mL/min of a 0.2-mEq/mL solution; correct 1/3 to 1/2 of Cl deficit while monitoring pH and Cl; administer remainder as needed |
| Amphotericin B colloidal dispersion (ABCD) | 3-5 mg/kg q24h | In 500 mL; final concentration range 0.16-0.83 mg/mL | Infuse at 1 mg/kg/h |
| Amphotericin B deoxycholate | 0.5-1.5 mg/kg q24h | In 250 mL | Infuse over 2-6 hours |
| Amphotericin B lipid complex (ABLC) | 3-5 mg/kg q24h | In 250 mL | Infuse over 2 hours; maximum rate of 2.5 mg/kg/h |
| Amphotericin B liposomal | 3-7 mg/kg q24h | In 250 mL | Infuse over 1-2 hours |
| | | | Do not mix in electrolyte solutions (eg, saline, lactated Ringer solution) |
| Ampicillin | 0.5-3 g q4-6h | In 100 mL | Infuse over 15-30 minutes |
| Ampicillin/sulbactam | 1.5-3 g q6h | In 100 mL | Infuse over 15-30 minutes |
| Argatroban |
| Percutaneous coronary intervention | 350 mcg/kg bolus, followed by 25 mcg/kg/min infusion | 250 mg in 250 mL | Infuse bolus over 3-5 minutes; titrate to aPTT or ACT |
| Heparin-induced thrombocytopenia with thrombosis | 0.5-1 mcg/kg/min in critically ill | 250 mg in 250 mL | Titrate to aPTT; initial dose increased to 2 mcg/kg/min in non-critically ill |
| Atracurium |
| Intubating dose | 0.4-0.5 mg/kg | Undiluted | Inject over 60 ... |